' 
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.2
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1/4 Level Teaspoon (1.1 g)
Amount Per Serving
%DV
Vitamin C (Ascorbic Acid)
1.1 g (1,100 mg)
1222%
Top Medical Research Studies
8
Vitamin C may reduce breast cancer
The association between vitamin C and breast cancer, prostate cancer and colorectal cancer: A systematic review and meta-analysis.
Study highly relevant to topic.
We examined the relationship between vitamin C and breast cancer through a systematic review and meta-analysis of various studies. By analyzing data from both cohort and case-control studies, we aimed to ascertain how dietary vitamin C affects breast cancer risk.
Our findings reveal an interesting trend. While we found that dietary vitamin C consumption was inversely related to breast cancer risk in case-control studies, showing a significant reduction in breast cancer incidence, the results from cohort studies presented a pooled relative risk (RR) of 0.99. This indicates no substantial association in those comprehensive, long-term observations.
Moreover, our review highlighted that there was no notable connection between vitamin E and breast cancer, suggesting that more research is needed to understand the complete impact of these nutrients. Overall, while the case-control study results are promising, the cohort studies suggest that more nuanced insights might be necessary before making solid conclusions about vitamin C as a preventive measure against breast cancer.
Our findings reveal an interesting trend. While we found that dietary vitamin C consumption was inversely related to breast cancer risk in case-control studies, showing a significant reduction in breast cancer incidence, the results from cohort studies presented a pooled relative risk (RR) of 0.99. This indicates no substantial association in those comprehensive, long-term observations.
Moreover, our review highlighted that there was no notable connection between vitamin E and breast cancer, suggesting that more research is needed to understand the complete impact of these nutrients. Overall, while the case-control study results are promising, the cohort studies suggest that more nuanced insights might be necessary before making solid conclusions about vitamin C as a preventive measure against breast cancer.
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7
Vitamin C kills breast cancer cells
Pharmacological Vitamin C-induced high HO generation mediates apoptotic cell death by caspase 3/7 activation in breast cancer tumor spheroids.
Direct evaluation of vitamin C
We explored the potential of high-dose vitamin C as a treatment for breast cancer using realistic 3D tumor models. By creating two types of breast cancer spheroids from cell lines MDA-MB-231 and MCF-7, we treated them with various concentrations of vitamin C, ranging from 1 to 20 mM. Our goal was to investigate vitamin C's effectiveness in killing cancer cells and to understand the biological mechanisms at play.
Our findings revealed that vitamin C prompted cell death in a dose-dependent manner in both types of spheroids. This was largely due to the production of hydrogen peroxide and other oxidative stress markers, as well as the depletion of protective antioxidants like glutathione. Remarkably, we noticed greater sensitivity to vitamin C in MCF-7 cells, while the more aggressive MDA-MB-231 cells showed even more significant destruction in response to treatment.
Overall, our study suggests that vitamin C could serve as a promising option for targeting breast cancer cells. By examining its effects on different breast cancer cell types, we shed light on its potential as part of a tailored approach to treatment. Vitamin C's role in instigating cell death through oxidative stress is an important development in the ongoing search for effective cancer therapies.
Our findings revealed that vitamin C prompted cell death in a dose-dependent manner in both types of spheroids. This was largely due to the production of hydrogen peroxide and other oxidative stress markers, as well as the depletion of protective antioxidants like glutathione. Remarkably, we noticed greater sensitivity to vitamin C in MCF-7 cells, while the more aggressive MDA-MB-231 cells showed even more significant destruction in response to treatment.
Overall, our study suggests that vitamin C could serve as a promising option for targeting breast cancer cells. By examining its effects on different breast cancer cell types, we shed light on its potential as part of a tailored approach to treatment. Vitamin C's role in instigating cell death through oxidative stress is an important development in the ongoing search for effective cancer therapies.
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8
Vitamin C and nanoparticles in cancer
Iron oxide nanozymes enhanced by ascorbic acid for macrophage-based cancer therapy.
Complex interactions with vitamin C
We explored the potential of vitamin C as a cancer treatment, particularly in the context of breast cancer. Our study focused on the interaction between vitamin C and iron oxide nanoparticles, specifically wüstite (FeO) nanoparticles, which can catalyze the conversion of hydrogen peroxide into potent radicals that are toxic to cancer cells.
By examining how these nanoparticles affect vitamin C’s performance, we discovered varying pH levels impact their effectiveness. Interestingly, the presence of the nanoparticles can either amplify or diminish the cytotoxic effect of vitamin C, depending on how they are distributed within the cells.
Furthermore, treatment with vitamin C encouraged macrophages loaded with these nanoparticles to adopt a pro-inflammatory M1 phenotype. This shift significantly thwarted the growth of 4T1 breast cancer cells. Overall, our findings emphasize the promising role of combining vitamin C with nanozymes in cancer therapy, paving the way for innovative approaches in breast cancer treatment.
By examining how these nanoparticles affect vitamin C’s performance, we discovered varying pH levels impact their effectiveness. Interestingly, the presence of the nanoparticles can either amplify or diminish the cytotoxic effect of vitamin C, depending on how they are distributed within the cells.
Furthermore, treatment with vitamin C encouraged macrophages loaded with these nanoparticles to adopt a pro-inflammatory M1 phenotype. This shift significantly thwarted the growth of 4T1 breast cancer cells. Overall, our findings emphasize the promising role of combining vitamin C with nanozymes in cancer therapy, paving the way for innovative approaches in breast cancer treatment.
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Most Useful Reviews
9.5
Life-saving vitamins
After consuming this, I know two breast cancer patients who are leading normal lives. These vitamins transformed their health.
Read More
7.5
Immune system support
Excellent Vitamin C! It strengthens my immune system and safeguards against viruses, aiding in wound healing as well. It plays a crucial role in collagen synthesis, which supports tissue growth. Moreover, it is vital for the prevention of breast cancer and other cancers, helping to protect my body from negative stress factors.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.2
- All Researches
9
Lemongrass extract shows potential benefits
Nutritional Significance, Antimicrobial, Antioxidants, Anticancer, and Antiviral Activities of Lemongrass Leaves Extract and Its Application as Hepatoprotective Agent against CCl4-Induced Hepatic Injury in Rats.
Study focused on extract, not vitamin C
We explored the effects of lemongrass extract on liver health and cancer, with a focus on its nutritional properties and potential to help combat diseases like breast cancer. The study revealed that lemongrass extract is rich in bioactive components, including phenolic acids and flavonoids, which contribute to its powerful antioxidant activities.
While the extract showed an impressive ability to inhibit the growth of breast cancer cells by 81%, the specific impact of vitamin C within the lemongrass was not isolated or extensively detailed in this research. This indicates that while lemongrass extract may have positive effects against breast cancer, attributing those benefits solely to vitamin C would be unsubstantiated and misleading.
Furthermore, lemongrass extract demonstrated promising hepatoprotective qualities, reducing markers of liver damage in rats exposed to harmful substances. However, the study does not make claims about vitamin C's effectiveness independently as a treatment for breast cancer, and our findings should be interpreted in the context of the combined effects of various compounds in the extract. Overall, this research indicates a multifaceted approach to cancer treatment rather than a single focus on vitamin C alone.
While the extract showed an impressive ability to inhibit the growth of breast cancer cells by 81%, the specific impact of vitamin C within the lemongrass was not isolated or extensively detailed in this research. This indicates that while lemongrass extract may have positive effects against breast cancer, attributing those benefits solely to vitamin C would be unsubstantiated and misleading.
Furthermore, lemongrass extract demonstrated promising hepatoprotective qualities, reducing markers of liver damage in rats exposed to harmful substances. However, the study does not make claims about vitamin C's effectiveness independently as a treatment for breast cancer, and our findings should be interpreted in the context of the combined effects of various compounds in the extract. Overall, this research indicates a multifaceted approach to cancer treatment rather than a single focus on vitamin C alone.
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8
Vitamin C and curcumin synergy explored
In Silico and In Vitro Verification of the Effects of Chemotherapeutic Doxorubicin and 5-Fluorouracil in Combination With Curcumin and Vitamin C on MCF-7 Cells.
Moderate relevance to breast cancer
Our research aimed to understand how Vitamin C, when combined with curcumin and two common chemotherapy drugs—doxorubicin and 5-fluorouracil—affects MCF-7 breast cancer cells. We meticulously conducted both in silico analyses and in vitro experiments to evaluate the effectiveness of these combinations on cell viability and inflammation markers.
We discovered that the combination of Vitamin C with curcumin and chemotherapy did show some promising results, particularly in reducing cell viability by up to 28% after 24 hours. In our tests, curcumin and doxorubicin exhibited the strongest interaction with certain proteins involved in inflammation, whereas Vitamin C displayed moderate effects. Notably, the inflammatory marker IL-6 was significantly expressed in the presence of curcumin.
However, it's important to highlight that while Vitamin C showed some synergy with the chemotherapeutic agents in the context of inflammation, there wasn’t enough evidence to strongly confirm its isolated effectiveness in breast cancer treatment alone. Our findings indicate that Vitamin C, especially when paired with curcumin, offers potential benefits, but further research is needed to solidify its role in therapy.
We discovered that the combination of Vitamin C with curcumin and chemotherapy did show some promising results, particularly in reducing cell viability by up to 28% after 24 hours. In our tests, curcumin and doxorubicin exhibited the strongest interaction with certain proteins involved in inflammation, whereas Vitamin C displayed moderate effects. Notably, the inflammatory marker IL-6 was significantly expressed in the presence of curcumin.
However, it's important to highlight that while Vitamin C showed some synergy with the chemotherapeutic agents in the context of inflammation, there wasn’t enough evidence to strongly confirm its isolated effectiveness in breast cancer treatment alone. Our findings indicate that Vitamin C, especially when paired with curcumin, offers potential benefits, but further research is needed to solidify its role in therapy.
Read More
8
Vitamin C may reduce breast cancer
The association between vitamin C and breast cancer, prostate cancer and colorectal cancer: A systematic review and meta-analysis.
Study highly relevant to topic.
We examined the relationship between vitamin C and breast cancer through a systematic review and meta-analysis of various studies. By analyzing data from both cohort and case-control studies, we aimed to ascertain how dietary vitamin C affects breast cancer risk.
Our findings reveal an interesting trend. While we found that dietary vitamin C consumption was inversely related to breast cancer risk in case-control studies, showing a significant reduction in breast cancer incidence, the results from cohort studies presented a pooled relative risk (RR) of 0.99. This indicates no substantial association in those comprehensive, long-term observations.
Moreover, our review highlighted that there was no notable connection between vitamin E and breast cancer, suggesting that more research is needed to understand the complete impact of these nutrients. Overall, while the case-control study results are promising, the cohort studies suggest that more nuanced insights might be necessary before making solid conclusions about vitamin C as a preventive measure against breast cancer.
Our findings reveal an interesting trend. While we found that dietary vitamin C consumption was inversely related to breast cancer risk in case-control studies, showing a significant reduction in breast cancer incidence, the results from cohort studies presented a pooled relative risk (RR) of 0.99. This indicates no substantial association in those comprehensive, long-term observations.
Moreover, our review highlighted that there was no notable connection between vitamin E and breast cancer, suggesting that more research is needed to understand the complete impact of these nutrients. Overall, while the case-control study results are promising, the cohort studies suggest that more nuanced insights might be necessary before making solid conclusions about vitamin C as a preventive measure against breast cancer.
Read More
8
Vitamin C mitigates endometrial fibrosis
Oxidative stress drives endometrial fibrosis via TGF-β1/MAPK signaling pathway in breast cancer.
Relevance to fertility preservation
We investigated how vitamin C might influence endometrial health in women with breast cancer. To do this, we measured endometrial thickness in both breast cancer patients and healthy controls using transvaginal ultrasound. We also established a mouse model with breast cancer tumors to observe the effects of vitamin C on uterine pathology.
Our research revealed that breast cancer patients and the tumor-bearing mice had a significantly lower endometrial thickness compared to healthy individuals. Interestingly, the presence of tumor-related oxidative stress led to changes in gene expression linked to the extracellular matrix and the process of epithelial-mesenchymal transition (EMT).
We found that vitamin C treatment helped reduce the damage in the endometrial tissue. It inhibited the EMT process and collagen buildup, thereby preserving the structure of the uterus in our tumor-bearing mice models. This suggests that vitamin C might be beneficial in addressing endometrial fibrosis, driven by oxidative stress in breast cancer patients.
Overall, our findings indicate that vitamin C can play a valuable role in managing endometrial complications linked to breast cancer, potentially impacting fertility preservation efforts for younger patients facing this diagnosis.
Our research revealed that breast cancer patients and the tumor-bearing mice had a significantly lower endometrial thickness compared to healthy individuals. Interestingly, the presence of tumor-related oxidative stress led to changes in gene expression linked to the extracellular matrix and the process of epithelial-mesenchymal transition (EMT).
We found that vitamin C treatment helped reduce the damage in the endometrial tissue. It inhibited the EMT process and collagen buildup, thereby preserving the structure of the uterus in our tumor-bearing mice models. This suggests that vitamin C might be beneficial in addressing endometrial fibrosis, driven by oxidative stress in breast cancer patients.
Overall, our findings indicate that vitamin C can play a valuable role in managing endometrial complications linked to breast cancer, potentially impacting fertility preservation efforts for younger patients facing this diagnosis.
Read More
8
Vitamin C improves leukaemia treatment
Targeting the redox vulnerability of acute myeloid leukaemia cells with a combination of auranofin and vitamin C.
Score reflects limited vitamin C focus.
We explored the effects of auranofin (AUF) combined with vitamin C (VC) on leukaemia cells, particularly focusing on acute myeloid leukaemia (AML). This study found that the combination of AUF and VC was effective in killing leukaemic cell lines from various myeloid subtypes.
Early responses to the treatment included an increase in reactive oxygen species and a decrease in ATP levels, which led to a significant stop in protein synthesis. These changes suggest that the AUF and VC pairing may trigger cell death in leukaemic cells.
Moreover, the combination therapy appeared to be particularly effective in eliminating primary AML cells from many patients’ samples, with less toxicity observed in normal cells. This points to a potential therapeutic approach that could specifically exploit the redox vulnerabilities present in AML, making it an exciting area for future research.
Early responses to the treatment included an increase in reactive oxygen species and a decrease in ATP levels, which led to a significant stop in protein synthesis. These changes suggest that the AUF and VC pairing may trigger cell death in leukaemic cells.
Moreover, the combination therapy appeared to be particularly effective in eliminating primary AML cells from many patients’ samples, with less toxicity observed in normal cells. This points to a potential therapeutic approach that could specifically exploit the redox vulnerabilities present in AML, making it an exciting area for future research.
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User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Life-saving vitamins
After consuming this, I know two breast cancer patients who are leading normal lives. These vitamins transformed their health.
7.5
Immune system support
Excellent Vitamin C! It strengthens my immune system and safeguards against viruses, aiding in wound healing as well. It plays a crucial role in collagen synthesis, which supports tissue growth. Moreover, it is vital for the prevention of breast cancer and other cancers, helping to protect my body from negative stress factors.
Read More
